Background and aims: Noise is one of the harmful parameters of the industrial environments. It affects the human health in different aspects including harmful effects on hearing damage, vision, neurological and psychiatric, hormones, physiological and mental systems. Paying attention to the importance of hormonal effects on human body, the aim of the present study is to investigate the effects of noise exposure on variation of serum levels of Glucose and Cortisol at Syrian adult male mouse. 
Methods: 36 Syrian adult male mice were randomly selected in six experiment and control groups. The experimental group was at condition of exposure to noise with 90dB intensity in frequency range of 700-5700 Hz. The control group was at the same condition with injection of Streptozotocin (in amount of 60mg/kg). Cool Edit software was used for noise generation and control in 30days (8hours per day). Finally, the mice fasting Cortisol and blood pressure levels were measured 24h after finishing of the exposure period for mice of the both groups. 
Results: the present research indicated that the Glucose level had significant difference (P < 0.002) in diabetic and non-diabetic samples with noise exposure. Also, Cortisol level had significant difference (P < 0.002) in diabetic and non-diabetic samples with noise exposure. 
Conclusion: Exposure to noise with 90dB intensity at frequency range of 700-5700Hz can increase the serum levels of Glucose and Cortisol. Hence, variation indicated that diet with 1% of garlic has not affected the Cortisol hormone and blood sugar levels during the exposure period.