Volume 4, Issue 1 (sprig&summer(number 1&2) 2007)                   ioh 2007, 4(1): 29-35 | Back to browse issues page

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Bakand S, Ameri A, Farshad A. Toxicity assessment of chemical contaminants transition from in vitromethods to novel in vitro methods. ioh. 2007; 4 (1) :29-35
URL: http://ioh.iums.ac.ir/article-1-459-en.html
Assistant professor Iran University of Medical Sciences. Tehran, Iran.
Abstract:   (6081 Views)

Exposure to occupational and environmental contaminants is a major contributor to human health problems. Despite significant achievements in the risk assessment of chemicals, the toxicological database, particularly for industrial chemicals, remains limited. Considering there are

approximately 80, 000 chemicals in commerce, and an extremely large number of chemical mixtures, in vivo testing of this large number is unachievable from ethical, economical and scientific perspectives. Therefore, increasing the number of available industrial chemicals and

new products has created a demand for alternatives to animal methods for better safety evaluation. Recent toxicity studies have demonstrated that in vitro methods are capable of rapidly providing toxicity information. In this review, current toxicity test methods for risk evaluation of industrial chemical contaminants are presented. To evaluate the potential applications of  more recent test methods developed for toxicity testing of chemical contaminants are discussed. Although  to be considered more broadly for risk assessment of human chemical exposures.

In vitro methods,in vitro toxicology methods cannot exactly mimic the biodynamics of the whole body, in vitro  relationships (QSARs) and physiologically based toxicokinetic (PBTK) models have a potentialtest systems in combination with the knowledge of quantitative structure activity.
Full-Text [PDF 294 kb]   (1719 Downloads)    
Type of Study: Research | Subject: Ergonomics,Production and productivity
Received: 2011/07/30

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