Iran Occupational Health Journal
سلامت كار ايران
ioh
Medical Sciences
http://ioh.iums.ac.ir
136
journal136
1735-5133
2228-7493
10.61186/ioh
fa
jalali
1386
1
1
gregorian
2007
4
1
4
1
online
1
fulltext
fa
مروری بر روشهای ارزیابی سمیت مواد شیمیایی، گذار از روشهای اینویوو به روشهای نوین اینویترو
Toxicity assessment of chemical contaminants transition from in vitromethods to novel in vitro methods
ارگونومی تولید و بهره وری
Ergonomics,Production and productivity
پژوهشي
Research
<font face="TimesNewRomanPSMT"><p align="left">Exposure to occupational and environmental contaminants is a major contributor to human health problems. Despite significant achievements in the risk assessment of chemicals, the toxicological database, particularly for industrial chemicals, remains limited. Considering there are</p><p align="left">approximately 80, 000 chemicals in commerce, and an extremely large number of chemical mixtures, in vivo testing of this large number is unachievable from ethical, economical and scientific perspectives. Therefore, increasing the number of available industrial chemicals and</p><p align="left">new products has created a demand for alternatives to animal methods for better safety evaluation. Recent toxicity studies have demonstrated that in vitro methods are capable of rapidly providing toxicity information. In this review, current toxicity test methods for risk evaluation of industrial chemical contaminants are presented. To evaluate the potential applications of more recent test methods developed for toxicity testing of chemical contaminants are discussed. Although to be considered more broadly for risk assessment of human chemical exposures. </p></font><em><font face="TimesNewRomanPS-ItalicMT">In vitro </font><font face="TimesNewRomanPSMT">methods,</font></em><font face="TimesNewRomanPS-ItalicMT"><em>in vitro</em> </font><font face="TimesNewRomanPSMT">toxicology methods cannot exactly mimic the biodynamics of the whole body,</font><font face="TimesNewRomanPS-ItalicMT"> in vitro relationships (QSARs) and physiologically based toxicokinetic (PBTK) models have a potential</font><font face="TimesNewRomanPSMT">test systems in combination with the knowledge of quantitative structure activity.</font>
آلاینده های شیمیایی،ارزیابی خطر، سم شناسی،اینویترو،اینویوو
Chemical contaminants, risk assessment, toxicology, in vitro, in vivo
29
35
http://ioh.iums.ac.ir/browse.php?a_code=A-10-1-33&slc_lang=fa&sid=1
SH.
Bakand
شهناز
باکند
1360031947532846002775
1360031947532846002775
Yes
Iran University of Medical Sciences. Tehran, Iran.
دانشکده بهداشت دانشگاه علوم پزشکی ایران
A.
Ameri
احمد
عامری
1360031947532846002776
1360031947532846002776
No
Iran University of Medical Sciences. Tehran, Iran.
دانشکده بهداشت دانشگاه علوم پزشکی ایران
A.A.
Farshad
علی اصغر
فرشاد
1360031947532846002777
1360031947532846002777
No
Iran University of Medical Sciences. Tehran, Iran.
دانشکده بهداشت دانشگاه علوم پزشکی ایران